The nucleus accumbens: a comprehensive review
S Salgado, MG Kaplitt - Stereotactic and functional neurosurgery, 2015 - karger.com
There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …
therapies to impact upon diseases beyond movement disorders and pain. A target of …
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
BJ Everitt, TW Robbins - Nature neuroscience, 2005 - nature.com
Drug addiction is increasingly viewed as the endpoint of a series of transitions from initial
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …
Opiate versus psychostimulant addiction: the differences do matter
The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories–indications for novel treatments of addiction
BJ Everitt - European Journal of Neuroscience, 2014 - Wiley Online Library
This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …
addiction can be understood in terms of interactions between Pavlovian and instrumental …
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
G Di Chiara - Behavioural brain research, 2002 - Elsevier
Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-
conditioned incentives. This abnormality has been explained by Incentive-Sensitization and …
conditioned incentives. This abnormality has been explained by Incentive-Sensitization and …
[HTML][HTML] Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement
The dopamine (DA) hypothesis posits the increase of mesolimbic dopamine levels as a
defining commonality of addictive drugs, initially causing reinforcement, eventually leading …
defining commonality of addictive drugs, initially causing reinforcement, eventually leading …
Neurobiology of relapse to heroin and cocaine seeking: a review
The objective of this article is to review data from studies that used a reinstatement model in
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …
Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction
In this review we discuss the evidence that drug addiction, defined as a maladaptive
compulsive habit, results from the progressive subversion by addictive drugs of striatum …
compulsive habit, results from the progressive subversion by addictive drugs of striatum …
Drug addiction and the memory systems of the brain
TW Robbins, KD Ersche… - Annals of the New York …, 2008 - Wiley Online Library
We review drug addiction from the perspective of the hypothesis that drugs of abuse interact
with distinct brain memory systems. We focus on emotional and procedural forms of memory …
with distinct brain memory systems. We focus on emotional and procedural forms of memory …
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing
effects of drugs of abuse. However, the precise function of the NAc itself in drug self …
effects of drugs of abuse. However, the precise function of the NAc itself in drug self …