Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development
The pandemic spread of a novel coronavirus–SARS coronavirus-2 (SARS-CoV-2) as a
cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of …
cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of …
Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
N Xiao, M Nie, H Pang, B Wang, J Hu, X Meng… - Nature …, 2021 - nature.com
Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal
outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can …
outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can …
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
R De Alwis, ES Gan, S Chen, YS Leong, HC Tan… - Molecular Therapy, 2021 - cell.com
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline …
Ensuring high vaccination and even booster vaccination coverage is critical in preventing
severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines …
severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines …
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic
approaches for the treatment of cancer. However, the efficacy of CAR NK/T cell therapy is …
approaches for the treatment of cancer. However, the efficacy of CAR NK/T cell therapy is …
Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination
COVID-19 vaccines are effective and important to control the ongoing pandemic, but vaccine
reactogenicity may contribute to poor uptake. Analgesics or antipyretic medications are often …
reactogenicity may contribute to poor uptake. Analgesics or antipyretic medications are often …
The effects of pre-existing antibodies on live-attenuated viral vaccines
Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus
spread, as well as for other applications such as cancer immunotherapy. However, with …
spread, as well as for other applications such as cancer immunotherapy. However, with …
[HTML][HTML] Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development
Zika virus (ZIKV) is an Aedes-mosquito-borne flavivirus that causes debilitating congenital
and developmental disorders. Improved understanding of ZIKV pathogenesis could assist …
and developmental disorders. Improved understanding of ZIKV pathogenesis could assist …