It is estimated that viral infections contribute to 15–20% of all human cancers. As obligatory
intracellular parasites, viruses encode proteins that reprogram host cellular signaling …

Viral and microbial constituents contain specific motifs or pathogen-associated molecular
patterns (PAMPs) that are recognized by cell surface-and endosome-associated Toll-like …

T-cell transformation by the human T-cell leukemia virus type I (HTLV-I) involves
deregulation of cellular transcription factors, including members of the NF-κB family. In …

Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

We identified SMYD2, a SMYD (SET and MYND domain) family protein with lysine
methyltransferase activity, as a novel breast cancer oncogene. SMYD2 was expressed at …

Activation of I-κB kinases (IKKs) and NF-κB by the human T lymphotropic virus type 1 (HTLV-
1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and …

Resistance towards apoptosis is a key factor for the survival of a malignant cell. Cancer
results if there is too little apoptosis and cells grow faster and live longer than normal cells. In …

Adult T-cell leukemia (ATL) is an aggressive hematologic malignancy caused by human T-
cell leukemia virus type I (HTLV-1). Tax, encoded by the HTLV-1 pX region, has been …

The nuclear factor of κB (NF-κB) family of heterodimeric transcription factors plays an
instrumental role in immune, inflammatory, and stress responses. NF-κB induces the …

While the classical pathway of NF-κB activation plays critical roles in a wide range of
biological processes, the more recently described “non-canonical” NF-κB pathway has …