Hypertrophic obstructive cardiomyopathy is an inherited myocardial disease defined by
cardiac hypertrophy (wall thickness≥ 15 mm) that is not explained by abnormal loading …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Muscle contraction consists of a cyclical interaction between myosin and actin driven by the
concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F …

Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families.
Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T …

The interaction of myosin with actin filaments is the central feature of muscle contraction and
cargo movement along actin filaments of the cytoskeleton. The energy for these movements …

Objectives: We investigated cardiac energetics in subjects with mutations in three different
familial hypertrophic cardiomyopathy (HCM) disease genes, some of whom were …

This review provides an historical and personal perspective on the discovery of genetic
causes for hypertrophic cardiomyopathy (HCM). Extraordinary insights by physicians who …

The muscle myosins are hexomeric proteins consisting of two heavy chains and two pairs of
light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize …

▪ Abstract Myosin is a highly conserved, ubiquitous protein found in all eukaryotic cells,
where it provides the motor function for diverse movements such as cytokinesis …

Hypertrophic cardiomyopathy is characterized by left and/or right ventricular hypertrophy,
which is usually asymmetric and involves the interventricular septum. Typical morphological …