[HTML][HTML] Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis
S Usman, NH Waseem, TKN Nguyen, S Mohsin… - Cancers, 2021 - mdpi.com
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …
functional support to the cell. During initial stages of cancer development, vimentin …
[HTML][HTML] Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …
robustness and resilience, enabling adaptation and increasing survival under dynamic …
NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …
[HTML][HTML] Vimentin intermediate filaments as potential target for cancer treatment
K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
[HTML][HTML] The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …
[HTML][HTML] Vimentin as a multifaceted player and potential therapeutic target in viral infections
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …
functions, and therefore in basic cellular processes such as cell division and migration …
[HTML][HTML] Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy
A Domingo-Muelas, RM Skory, AA Moverley… - Cell, 2023 - cell.com
Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …
implantation. Live imaging has uncovered major events driving early development in mouse …
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
H Wu, Y Shen, S Sivagurunathan… - Proceedings of the …, 2022 - National Acad Sciences
The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …
Unique role of vimentin networks in compression stiffening of cells and protection of nuclei from compressive stress
K Pogoda, F Byfield, P Deptuła, M Cieśluk… - Nano Letters, 2022 - ACS Publications
In this work, we investigate whether stiffening in compression is a feature of single cells and
whether the intracellular polymer networks that comprise the cytoskeleton (all of which stiffen …
whether the intracellular polymer networks that comprise the cytoskeleton (all of which stiffen …
[HTML][HTML] Nuclear lamins: Structure and function in mechanobiology
Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …