[HTML][HTML] Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis

S Usman, NH Waseem, TKN Nguyen, S Mohsin… - Cancers, 2021 - mdpi.com
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

[HTML][HTML] Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment

VDL Putra, KA Kilian, ML Knothe Tate - Communications Biology, 2023 - nature.com
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

HR Thiam, SL Wong, R Qiu… - Proceedings of the …, 2020 - National Acad Sciences
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …

[HTML][HTML] Vimentin intermediate filaments as potential target for cancer treatment

K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

[HTML][HTML] The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

SE Leggett, AM Hruska, M Guo, IY Wong - Cell Communication and …, 2021 - Springer
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

[HTML][HTML] Vimentin as a multifaceted player and potential therapeutic target in viral infections

I Ramos, K Stamatakis, CL Oeste… - International journal of …, 2020 - mdpi.com
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

[HTML][HTML] Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy

A Domingo-Muelas, RM Skory, AA Moverley… - Cell, 2023 - cell.com
Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …

Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex

H Wu, Y Shen, S Sivagurunathan… - Proceedings of the …, 2022 - National Acad Sciences
The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …

Unique role of vimentin networks in compression stiffening of cells and protection of nuclei from compressive stress

K Pogoda, F Byfield, P Deptuła, M Cieśluk… - Nano Letters, 2022 - ACS Publications
In this work, we investigate whether stiffening in compression is a feature of single cells and
whether the intracellular polymer networks that comprise the cytoskeleton (all of which stiffen …

[HTML][HTML] Nuclear lamins: Structure and function in mechanobiology

A Vahabikashi, SA Adam, O Medalia… - APL bioengineering, 2022 - pubs.aip.org
Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …