Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to
investigating fundamental cancer biology and developing novel treatment strategies that …

Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …

Disruption of cellular activities by pathogen virulence factors can trigger innate immune
responses. Interferon-γ (IFN-γ)–inducible antimicrobial factors, such as the guanylate …

This review comprehensively explores the challenge of drug resistance in cancer by
focusing on the pivotal PI3K/AKT/mTOR pathway, elucidating its role in oncogenesis and …

Global changes in transcriptional regulation and RNA metabolism are crucial features of
cancer development. However, little is known about the role of the core promoter in defining …

Background Local recurrence after surgery and radiochemotherapy seriously affects the
prognosis of locally advanced rectal cancer (LARC) patients. Studies on molecular markers …

Introduction Colorectal cancer is the third most common cause of cancer death. Rectal
cancer makes up a third of all colorectal cases. Treatment for locally advanced rectal cancer …

Neoadjuvant radiotherapy is commonly used as standard treatment for rectal cancer.
However, response rates are variable and survival outcomes remain poor, highlighting the …

Intestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal
cancer using organoids has emerged in the last decade. Human intestinal cancer organoids …

抗肿瘤药物的开发一直面临研发周期长, 体内药效差异大和个体间疗效差异等问题.
患者来源肿瘤类器官(PDTO) 是肿瘤细胞的三维培养物, 可以长期扩增, 模拟体内肿瘤特征及肿瘤 …