The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global health emergency, and its gene mutation and evolution further posed uncertainty of …

This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

Viable pathogenic bacteria cause serious human diseases via systemic infections and food
poisoning. Herein, we constructed a light-up RNA aptamer signaling-CRISPR-Cas13a …

Numerous studies have shown how RNA molecules can adopt elaborate three-dimensional
(3D) architectures,–. By contrast, whether DNA can self-assemble into complex 3D folds …

Pepper fluorescent RNAs are a recently reported bright, stable and multicolor fluorogenic
aptamer tag that enable imaging of diverse RNAs in live cells. To investigate the molecular …

The CRISPR/Cas system is a protective adaptive immune system against attacks from
foreign mobile genetic elements. Since the discovery of the excellent target-specific …

Genome editing technologies hold great promise for numerous applications including the
understanding of cellular and disease mechanisms and the development of gene and …

MicroRNAs (miRNAs) are a class of small, single-stranded, and non-coding RNA molecules
that act as post-transcriptional regulators of gene expression, participating in the regulation …