Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Over the past 60 years, chemotherapeutic agents that target thymidylate biosynthesis and
the enzyme thymidylate synthase (TS) have remained among the most-successful drugs …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …

Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …

Re-programming of metabolic pathways is a hallmark of physiological changes in cancer
cells. The expression of certain genes that directly control the rate of key metabolic pathways …

Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide
presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is …

Inhibition of nucleoside metabolism is an important principle in cancer therapy as evidenced
by the role of fluoropyrimidines, such as 5-fluorouracil (5-FU), and antifolates in the …

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies
have shown that abnormal nucleotide metabolism not only accelerates the development of …