A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Small RNA regulators and the bacterial response to stress

S Gottesman, CA McCullen, M Guillier… - Cold Spring Harbor …, 2006 - symposium.cshlp.org
Recent studies have uncovered dozens of regulatory small RNAs in bacteria. A large
number of these small RNAs act by pairingto their target mRNAs. The outcome of pairing …

C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

R Kaletsky, RS Moore, GD Vrla, LR Parsons, Z Gitai… - Nature, 2020 - nature.com
Caenorhabditis elegans must distinguish pathogens from nutritious food sources among the
many bacteria to which it is exposed in its environment. Here we show that a single …

Pervasive regulatory functions of mRNA structure revealed by high-resolution SHAPE probing

AM Mustoe, S Busan, GM Rice, CE Hajdin… - Cell, 2018 - cell.com
Summary mRNAs can fold into complex structures that regulate gene expression. Resolving
such structures de novo has remained challenging and has limited our understanding of the …

An atlas of Hfq‐bound transcripts reveals 3′ UTRs as a genomic reservoir of regulatory small RNAs

Y Chao, K Papenfort, R Reinhardt, CM Sharma… - The EMBO …, 2012 - embopress.org
The small RNAs associated with the protein Hfq constitute one of the largest classes of post‐
transcriptional regulators known to date. Most previously investigated members of this class …

Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes

Z Weinberg, JX Wang, J Bogue, J Yang, K Corbino… - Genome biology, 2010 - Springer
Abstract Background Structured noncoding RNAs perform many functions that are essential
for protein synthesis, RNA processing, and gene regulation. Structured RNAs can be …

Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq

A Sittka, S Lucchini, K Papenfort, CM Sharma… - PLoS …, 2008 - journals.plos.org
Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a
thorough analysis of RNA bound to cellular proteins, and, therefore, of post-transcriptional …

Genome Diversity of Pseudomonas aeruginosa PAO1 Laboratory Strains

J Klockgether, A Munder, J Neugebauer… - Journal of …, 2010 - Am Soc Microbiol
Pseudomonas aeruginosa PAO1 is the most commonly used strain for research on this
ubiquitous and metabolically versatile opportunistic pathogen. Strain PAO1, a derivative of …

The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing

A Dötsch, D Eckweiler, M Schniederjans… - PloS one, 2012 - journals.plos.org
In this study, we evaluated how gene expression differs in mature Pseudomonas aeruginosa
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …

Translational control and target recognition by Escherichia coli small RNAs in vivo

JH Urban, J Vogel - Nucleic acids research, 2007 - academic.oup.com
Small non-coding RNAs (sRNAs) are an emerging class of regulators of bacterial gene
expression. Most of the regulatory Escherichia coli sRNAs known to date modulate …