Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Genetic networks are characterized by extensive buffering. During tumor evolution,
disruption of functional redundancies can create de novo vulnerabilities that are specific to …

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …

Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated
with increased risk for morbidity and mortality. The CD99 gene, positioned in the …

Abstract Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic
clones—can differ in frequency and cellular fitness by CH type (eg, mutations in driver genes …

Genome-wide association studies (GWAS) have identified thousands of germline
susceptibility loci associated with risk for cancer as well as a wide range of other traits and …

Background: Glyphosate is the most commonly used herbicide worldwide and has been
implicated in the development of certain hematologic cancers. Although mechanistic studies …

Background The COVID-19 pandemic, which has a prominent social and economic impact
worldwide, shows a largely unexplained male bias for the severity and mortality of the …