Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

G Vauquelin, SJ Charlton - British journal of pharmacology, 2010 - Wiley Online Library
An increasing number of examples in the literature suggest that the in vivo duration of drug
action not only depends on macroscopic pharmacokinetic properties like plasma half‐life …

Resurrection and reactivation of acetylcholinesterase and butyrylcholinesterase

AJ Franjesevic, SB Sillart, JM Beck… - … A European Journal, 2019 - Wiley Online Library
Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian
and military populations. OP compounds include the nefarious G and V chemical nerve …

[图书][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues

X Wu, JM An, J Shang, E Huh, S Qi, E Lee, H Li… - Chemical …, 2020 - pubs.rsc.org
Acetylcholinesterase (AChE) is an extremely critical hydrolase tightly associated with
neurological diseases. Currently, developing specific substrates for imaging AChE activity …

Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin

N Schmidt, M Akaaboune, N Gajendran… - Journal of Cell …, 2011 - rupress.org
Neuregulin (NRG)/ErbB signaling is involved in numerous developmental processes in the
nervous system, including synapse formation and function in the central nervous system …

Molecular mechanisms for nicotine intoxication

T Alkam, T Nabeshima - Neurochemistry International, 2019 - Elsevier
Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once
used as pesticides in agriculture. Although its use in agriculture is prohibited in many …

The neuromuscular junction

AG Engel - Handbook of clinical neurology, 2008 - Elsevier
Publisher Summary The neuromuscular junction (NMJ) is a chemical synapse that is
anatomically and functionally differentiated for the transmission of a signal from the motor …

Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and …

AA Dos Santos, AA Naime, J de Oliveira, D Colle… - Archives of …, 2016 - Springer
The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute
toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to …

β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure

AE Vanhaesebrouck, R Webster, S Maxwell… - Brain, 2019 - academic.oup.com
Acetylcholine receptor deficiency is the most common form of the congenital myasthenic
syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission …

An investigation of the neurotoxic effects of malathion, chlorpyrifos, and paraquat to different brain regions

E Elmorsy, A Al-Ghafari, H Al Doghaither, M Salama… - Brain sciences, 2022 - mdpi.com
Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential
development of neurodegenerative diseases (NDDs). This study aimed to consider the …