Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action
G Vauquelin, SJ Charlton - British journal of pharmacology, 2010 - Wiley Online Library
An increasing number of examples in the literature suggest that the in vivo duration of drug
action not only depends on macroscopic pharmacokinetic properties like plasma half‐life …
action not only depends on macroscopic pharmacokinetic properties like plasma half‐life …
Resurrection and reactivation of acetylcholinesterase and butyrylcholinesterase
AJ Franjesevic, SB Sillart, JM Beck… - … A European Journal, 2019 - Wiley Online Library
Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian
and military populations. OP compounds include the nefarious G and V chemical nerve …
and military populations. OP compounds include the nefarious G and V chemical nerve …
[图书][B] Handbook of venoms and toxins of reptiles
SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
A molecular approach to rationally constructing specific fluorogenic substrates for the detection of acetylcholinesterase activity in live cells, mice brains and tissues
Acetylcholinesterase (AChE) is an extremely critical hydrolase tightly associated with
neurological diseases. Currently, developing specific substrates for imaging AChE activity …
neurological diseases. Currently, developing specific substrates for imaging AChE activity …
Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin
N Schmidt, M Akaaboune, N Gajendran… - Journal of Cell …, 2011 - rupress.org
Neuregulin (NRG)/ErbB signaling is involved in numerous developmental processes in the
nervous system, including synapse formation and function in the central nervous system …
nervous system, including synapse formation and function in the central nervous system …
Molecular mechanisms for nicotine intoxication
T Alkam, T Nabeshima - Neurochemistry International, 2019 - Elsevier
Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once
used as pesticides in agriculture. Although its use in agriculture is prohibited in many …
used as pesticides in agriculture. Although its use in agriculture is prohibited in many …
The neuromuscular junction
AG Engel - Handbook of clinical neurology, 2008 - Elsevier
Publisher Summary The neuromuscular junction (NMJ) is a chemical synapse that is
anatomically and functionally differentiated for the transmission of a signal from the motor …
anatomically and functionally differentiated for the transmission of a signal from the motor …
Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and …
AA Dos Santos, AA Naime, J de Oliveira, D Colle… - Archives of …, 2016 - Springer
The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute
toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to …
toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to …
β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure
AE Vanhaesebrouck, R Webster, S Maxwell… - Brain, 2019 - academic.oup.com
Acetylcholine receptor deficiency is the most common form of the congenital myasthenic
syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission …
syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission …
An investigation of the neurotoxic effects of malathion, chlorpyrifos, and paraquat to different brain regions
Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential
development of neurodegenerative diseases (NDDs). This study aimed to consider the …
development of neurodegenerative diseases (NDDs). This study aimed to consider the …