A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling
contributes to not only immunity, but also inflammation, cancer, and nervous system function …

The nuclear factor-kappa B (NF-κB) signaling pathway regulates a variety of biological
functions in the body, and its abnormal activation contributes to the pathogenesis of many …

This review presents current knowledge related to VDAC1 as a multi-functional
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …

Endothelial inflammation and mitochondrial dysfunction have been implicated in
cardiovascular diseases, yet, a unifying mechanism tying them together remains limited …

Mitochondrial dysfunction is one of the major contributors to neurodegenerative disorders
including Parkinson disease. The mitochondrial permeability transition pore is a protein …

Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating
signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing …

The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

Diabetes is the leading cause of chronic kidney disease worldwide. Despite the burden, the
factors contributing to the development and progression of diabetic kidney disease (DKD) …

Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a
long time only for its telomere lengthening function by reverse transcription of RNA template …

Currently, the clinical utility of taxane-based drug formulations in castration-resistant prostate
cancer (CRPC) is severely limited by acquired chemotherapy resistance, dose-limiting …