Liver-stage malaria parasites vulnerable to diverse chemical scaffolds
ER Derbyshire, M Prudêncio… - Proceedings of the …, 2012 - National Acad Sciences
Human malaria infection begins with a one-time asymptomatic liver stage followed by a
cyclic symptomatic blood stage. All high-throughput malaria drug discovery efforts have …
cyclic symptomatic blood stage. All high-throughput malaria drug discovery efforts have …
Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach
NM Vandevelde, PM Tulkens, F Van Bambeke - Drug discovery today, 2016 - Elsevier
Highlights•Non-antibiotic drugs show antibacterial effects alone or combined with
antibiotics.•Acting on bacteria, they modulate efflux, survival in biofilm or intracellularly.•They …
antibiotics.•Acting on bacteria, they modulate efflux, survival in biofilm or intracellularly.•They …
Generic pharmaceuticals, regulatory aspects, bioequivalence investigation, and perception
R Bhushan, J Martens - Expert Opinion on Drug Safety, 2024 - Taylor & Francis
Introduction The objective and significance of the topic is to draw attention toward regulatory
aspects (and pharmacopoeias) for bioequivalence investigation, and perception for generic …
aspects (and pharmacopoeias) for bioequivalence investigation, and perception for generic …
Factors contributing to drug release from enteric-coated omeprazole capsules: an in vitro and in vivo pharmacokinetic study and IVIVC evaluation in beagle dogs
C Cui, J Sun, X Wang, Z Yu, Y Shi - Dose-Response, 2020 - journals.sagepub.com
This study was performed to explore factors influencing the release of the proton pump
inhibitor omeprazole from enteric-coated capsules in vitro and absorption in vivo in beagle …
inhibitor omeprazole from enteric-coated capsules in vitro and absorption in vivo in beagle …
Comparative pharmacokinetics/pharmacodynamics of fixed-dose combination of esomeprazole and calcium carbonate (AD-206) to the conventional esomeprazole
S Bae, J Kwon, SB Lee, IJ Jang, KS Yu… - Drug Design …, 2021 - Taylor & Francis
Purpose Proton pump inhibitors (PPIs) are used for the treatment of acid-related disorders.
Demands for enhanced stability and faster onset led to the development of AD-206, a fixed …
Demands for enhanced stability and faster onset led to the development of AD-206, a fixed …
Synthesis, characterization, and pharmacodynamics study of enrofloxacin mesylate
L Pei, W Yang, J Fu, M Liu, T Zhang, D Li… - Drug design …, 2020 - Taylor & Francis
Introduction Enrofloxacin is used in the treatment of a wide variety of bacterial infections in
mammals. However, its poor solubility limits the clinical use. Methods In order to improve the …
mammals. However, its poor solubility limits the clinical use. Methods In order to improve the …
Pharmacokinetic comparison study of a combination containing 500 mg of naproxen and 20 mg of esomeprazole: a randomized, single-dose, 2-way crossover, open …
HG Choi, JY Jeon, SS Kwak, H Kim, C Jin, YJ Im… - Clinical …, 2015 - Elsevier
Purpose Nonsteroidal anti-inflammatory drugs have been used for analgesic, anti-
inflammatory, and antithrombotic effects, but they carry a risk of major gastrointestinal …
inflammatory, and antithrombotic effects, but they carry a risk of major gastrointestinal …
Kinetics of Omeprazole Release from Enteric Dosage Forms of Different Manufacturers
SY Serebrova, DO Kurguzova, LM Krasnykh… - Pharmaceutical …, 2024 - Springer
A comparative dissolution kinetics test (CDKT) related to proton-pump inhibitors (PPIs),
particularly omeprazole, using dissolution media with pH 1.2 and 6.8 does not take into …
particularly omeprazole, using dissolution media with pH 1.2 and 6.8 does not take into …
Pharmacokinetics and bioequivalence study of esomeprazole magnesium enteric-coated tablets 20 mg in healthy Chinese subjects under fasting and fed conditions
Y Ding, N Chu, L Que, K Huang, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Objective: The main purpose of this study was to evaluate the pharmacokinetics,
bioequivalence, and safety properties between a new generic and a brand reference …
bioequivalence, and safety properties between a new generic and a brand reference …
A Simple RP? HPLC Method for the Determination of Cefdinir in Human Serum: Validation and Application in a Pharmacokinetic Study with Healthy Bangladeshi Male …
In the present study, a simple RP? HPLC method with UV detection has been validated to
determine cefdinir concentrations in human serum samples and applied to determine the …
determine cefdinir concentrations in human serum samples and applied to determine the …