Amyotrophic lateral sclerosis (ALS) is a rare progressive motor neuron disease that, due to
its high complexity, still lacks effective treatments. Development of a new drug is a highly …

Abstract Glucagon-like peptide-1 (GLP-1) receptor agonist-based drugs (incretin mimetics)
have meaningfully impacted current treatment of type 2 diabetes mellitus (T2DM), and their …

The vast majority of current cereblon (CRBN) ligands is based on the thalidomide scaffold,
relying on glutarimide as the core binding moiety. With this architecture, most of these …

Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to
neurotoxicity, as observed in this study, where 100 µM of Mn was administered to the human …

Introduction Despite the recent full FDA approval of lecanemab, there is currently no disease
modifying therapy (DMT) that can efficiently slow down the progression of Alzheimer's …

Alzheimer's disease (AD) is a complex degenerative disease of the central nervous system
that is clinically characterized by a progressive decline in memory and cognitive function …