Children's Oncology Group's 2023 blueprint for research: Germ cell tumors

R Bhuta, R Shah, JJ Gell, JN Poynter… - Pediatric blood & …, 2023 - Wiley Online Library
Extracranial germ cell tumors (GCT) are a biologically diverse group of tumors occurring in
children, adolescents, and young adults. The majority of patients have excellent outcomes …

(Epi) genetic and Genomic Features of Pediatric and Adult Germ Cell Tumors

A Fichtner, S Zschäbitz, D Nettersheim… - Surgical Pathology …, 2024 - Elsevier
Germ cell tumors (GCTs) are a heterogeneous group of benign and malignant neoplasms
that most commonly arise in the gonads (about 95%) but can also primarily develop at …

Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

M Ní Leathlobhair, A Frangou, B Kinnersley… - Nature …, 2024 - nature.com
Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma
subtypes, are the most common cancers in young men. In this study, we present a …

Recent Advancements in Research on DNA Methylation and Testicular Germ Cell Tumors: Unveiling the Intricate Relationship

AT Nicu, IP Ionel, I Stoica, L Burlibasa, V Jinga - Biomedicines, 2024 - mdpi.com
Testicular germ cell tumors (TGCTs) are the most common type of testicular cancer, with a
particularly high incidence in the 15–45-year age category. Although highly treatable …

Wnt10a downregulation contributes to MEHP-induced disruption of self-renewal and differentiation balance and proliferation inhibition in GC-1 cells: insights from …

Y Hong, X Zhou, Q Li, J Chen, Y Wei, S Wang… - Environmental …, 2023 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP), one of phthalic acid esters, has been widely
used in daily products. Its main metabolite, mono (2-ethylhexyl) phthalate (MEHP) was …

Children's Oncology Group's 2023 blueprint for research: Epidemiology

PJ Lupo, EL Marcotte, ME Scheurer… - Pediatric Blood & …, 2023 - Wiley Online Library
Abstract The Children's Oncology Group (COG) Epidemiology Committee has a primary
focus on better understanding the etiologies of childhood cancers. Over the past 10 years …

Beta-Catenin Alterations in Postchemotherapy Yolk Sac Tumor, Postpubertal-Type With Enteroblastic Features

A Surucu, D de Biase, C Ricci, L di Sciascio, K Collins… - Modern Pathology, 2024 - Elsevier
Postchemotherapy postpubertal-type yolk sac tumors (YST) with glandular and solid
phenotypes are aggressive and commonly resistant to systemic chemotherapy. These …

Multi-cohort validation: A comprehensive exploration of prognostic marker in clear cell renal cell carcinoma

Y Li, C Fan, Y Hu, W Zhang, H Li, Y Wang… - International …, 2024 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is the most common form of RCC. It is characterized
by resistance to traditional radiotherapy and chemotherapy, as well as an unfavorable …