Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in
synaptic plasticity and memory processes, resulting in an increase of cAMP response …

Tau is a microtubule-associated protein widely distributed in the central nervous system
(CNS). The main function of tau is to promote the assembly of microtubules and stabilize …

Nitric oxide (NO) is a gaseous molecule that plays a multifactorial role in several cellular
processes. In the central nervous system, the NO dual nature in neuroprotection and …

Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment, memory loss, and behavioral deficits. β-amyloid1–42 (Aβ1–42) aggregation is a …

Increasing human life expectancy prompts the development of novel remedies for cognitive
decline: 44 million people worldwide are affected by dementia, and this number is predicted …

Alzheimer's disease (AD) is characterized by cognitive impairment and the presence of
neurofibrillary tangles and senile plaques in the brain. Neurofibrillary tangles are composed …

Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of
neurodegenerative diseases, including Alzheimer's disease (AD). Hitherto, sample sizes …