In recent years, there has been a growing interest in therapeutic peptides within the
pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …

Site-selective functionalization of complex molecules is one of the most significant
challenges in chemistry. Typically, protecting groups or catalysts must be used to enable the …

Stapled peptides are a promising class of alpha-helix mimetic inhibitors for protein–protein
interactions. We report the divergent synthesis of “functionalised” stapled peptides via an …