Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Live-cell mass profiling: an emerging approach in quantitative biophysics

TA Zangle, MA Teitell - Nature methods, 2014 - nature.com
Cell mass, volume and growth rate are tightly controlled biophysical parameters in cellular
development and homeostasis, and pathological cell growth defines cancer in metazoans …

Tumor cell escape from therapy-induced senescence

T Saleh, L Tyutyunyk-Massey, GF Murray… - Biochemical …, 2019 - Elsevier
H460 non-small cell lung, HCT116 colon and 4T1 breast tumor cell lines induced into
senescence by exposure to either etoposide or doxorubicin were able to recover …

Drug screening at single-organoid resolution via bioprinting and interferometry

PJ Tebon, B Wang, AL Markowitz, A Davarifar… - Nature …, 2023 - nature.com
High throughput drug screening is an established approach to investigate tumor biology and
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …

Label-free high-throughput cell screening in flow

A Mahjoubfar, C Chen, KR Niazi… - Biomedical optics …, 2013 - opg.optica.org
Flow cytometry is a powerful tool for cell counting and biomarker detection in biotechnology
and medicine especially with regards to blood analysis. Standard flow cytometers perform …

High-speed live-cell interferometry: a new method for quantifying tumor drug resistance and heterogeneity

D Huang, KA Leslie, D Guest, O Yeshcheulova… - Analytical …, 2018 - ACS Publications
We report the development of high-speed live-cell interferometry (HSLCI), a new
multisample, multidrug testing platform for directly measuring tumor therapy response via …

Soft lithography fabrication of index-matched microfluidic devices for reducing artifacts in fluorescence and quantitative phase imaging

DNH Kim, KT Kim, C Kim, MA Teitell… - Microfluidics and …, 2018 - Springer
Microfluidic devices are widely used for biomedical applications based on microscopy or
other optical detection methods. However, the materials commonly used for microfabrication …

LVING reveals the intracellular structure of cell growth

S Pradeep, TA Zangle - Scientific Reports, 2024 - nature.com
The continuous balance of growth and degradation inside cells maintains homeostasis.
Disturbance of this balance by internal or external factors cause state of disease, while …

Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging

S Pradeep, T Tasnim, H Zhang, TA Zangle - Analyst, 2021 - pubs.rsc.org
Measurement of neuron behavior is crucial for studying neural development and evaluating
the impact of potential therapies on neural regeneration. Conventional approaches to …

Physical cytometry: detecting mass-related properties of single cells

Y Zhao, L Gu, H Sun, X Sha, WJ Li - ACS sensors, 2022 - ACS Publications
The physical properties of a single cell, such as mass, volume, and density, are important
indications of the cell's metabolic characteristics and homeostasis. Precise measurement of …