The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …

Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four
major steps: attachment and entry into a target cell, replication of the viral genome …

Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …

Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …

HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can lead to the development of HIV-1-associated dementia (HAD). We examined the …

With the introduction of combination antiretroviral therapy AIDS dementia complex or HIV-
associated dementia, as it was termed later, largely disappeared in clinical practice …

HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV
(PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be …

HIV-associated central nervous system (CNS) injury continues to be clinically significant in
the modern era of HIV infection and therapy. A substantial proportion of patients with …

Introduction: Several CSF biomarkers of neuronal injury have been studied in people living
with HIV. At this time, the most useful is the light subunit of the neurofilament protein (NFL) …