Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - ASPET
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

50 years of oral lipid-based formulations: provenance, progress and future perspectives

OM Feeney, MF Crum, CL McEvoy, NL Trevaskis… - Advanced drug delivery …, 2016 - Elsevier
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

[HTML][HTML] Oral lipid-based drug delivery systems–an overview

S Kalepu, M Manthina, V Padavala - Acta Pharmaceutica Sinica B, 2013 - Elsevier
The formulation of drugs is carried out with the principle objective of enhancing their
bioavailability. Poorly water soluble drugs are challenging for the formulation scientists with …

[图书][B] Nanoparticle-and microparticle-based delivery systems: Encapsulation, protection and release of active compounds

DJ McClements - 2014 - books.google.com
This book covers the formation, properties, characterization, and application of different
kinds of colloidal delivery systems that can be utilized within the food industry, including …

[图书][B] Food emulsions: principles, practices, and techniques

DJ McClements - 2004 - taylorfrancis.com
Food Emulsions: Principles, Practice, and Techniques, Second Edition introduces the
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …

Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components

DJ McClements, Y Li - Advances in colloid and interface science, 2010 - Elsevier
There is a need for edible delivery systems to encapsulate, protect and release bioactive
and functional lipophilic constituents within the food and pharmaceutical industries. These …

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

CJH Porter, NL Trevaskis, WN Charman - Nature reviews Drug …, 2007 - nature.com
Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

Review of in vitro digestion models for rapid screening of emulsion-based systems

DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …

Enhancing intestinal drug solubilisation using lipid-based delivery systems

CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …