Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
[HTML][HTML] Oral lipid-based drug delivery systems–an overview
S Kalepu, M Manthina, V Padavala - Acta Pharmaceutica Sinica B, 2013 - Elsevier
The formulation of drugs is carried out with the principle objective of enhancing their
bioavailability. Poorly water soluble drugs are challenging for the formulation scientists with …
bioavailability. Poorly water soluble drugs are challenging for the formulation scientists with …
[图书][B] Nanoparticle-and microparticle-based delivery systems: Encapsulation, protection and release of active compounds
DJ McClements - 2014 - books.google.com
This book covers the formation, properties, characterization, and application of different
kinds of colloidal delivery systems that can be utilized within the food industry, including …
kinds of colloidal delivery systems that can be utilized within the food industry, including …
[图书][B] Food emulsions: principles, practices, and techniques
DJ McClements - 2004 - taylorfrancis.com
Food Emulsions: Principles, Practice, and Techniques, Second Edition introduces the
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …
Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components
DJ McClements, Y Li - Advances in colloid and interface science, 2010 - Elsevier
There is a need for edible delivery systems to encapsulate, protect and release bioactive
and functional lipophilic constituents within the food and pharmaceutical industries. These …
and functional lipophilic constituents within the food and pharmaceutical industries. These …
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …
contemporary drug discovery programmes and present a number of challenges to drug …
Review of in vitro digestion models for rapid screening of emulsion-based systems
DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …
Enhancing intestinal drug solubilisation using lipid-based delivery systems
CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …