We characterize the metabolic background in distinct Acute Myeloid Leukemias (AMLs), by
comparing the metabolism of primary AML blasts isolated at diagnosis with that of normal …

All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of
Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological …

Circadian rhythm is a periodic change of organism according to the law of external
environment, which is manifested in metabolism, cell proliferation, physiology and behavior …

Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its
exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly …

Neutral lipid storage disease type M (NLSD-M) is an ultra-rare, autosomal recessive
disorder that causes severe skeletal and cardiac muscle damage and lipid accumulation in …

The role played by lipids in the process of granulocytic differentiation activated by all-trans
retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown. The …

Acute promyelocytic leukemia (APL) is a hematological disease characterized by the
expression of the oncogenic fusion protein PML-RARα. The current treatment approach for …

This study aimed to explore the potential of Urtica dioica (U. dioica) ethanolic leaf extract for
cancer treatment by identifying its components, evaluating its effects on cancer cell lines …

Combining new therapeutics with all-trans-retinoic acid (ATRA) could improve the efficiency
of acute myeloid leukemia (AML) treatment. Modeling the process of ATRA-induced …

Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis,
neutropenia, and neutrophil dysfunction, is caused by a deficiency in glucose-6-phosphate …