Membrane proteins remain difficult to study by traditional methods. Magic angle spinning
solid-state NMR (MAS SSNMR) methods present an important approach for studying …

Biomolecular applications of NMR spectroscopy are often merely associated with soluble
molecules or magnetic resonance imaging. However, since the late 1970s, solid‐state NMR …

We report two structures of the human voltage-gated potassium channel (Kv) Kv1. 3 in
immune cells alone (apo-Kv1. 3) and bound to an immunomodulatory drug called dalazatide …

Dynamic nuclear polarization (DNP) has become a powerful method to enhance
spectroscopic sensitivity in the context of magnetic resonance imaging and nuclear …

Recent discoveries suggest cysteine-stabilized toxins and antimicrobial peptides have
structure–activity parallels derived by common ancestry. Here, human antimicrobial peptide …

It has been hypothesized that transmembrane allostery is the basis for inactivation of the
potassium channel KcsA: opening the intracellular gate is spontaneously followed by ion …

Supramolecular chemistry provides structural and conformational information about
complexes formed from multiple molecules. While the molecule is held together by strong …

The voltage-gated potassium channel KV1. 3 is an important therapeutic target for the
treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1. 3 …

Potassium (K+)‐channel gating is choreographed by a complex interplay between external
stimuli, K+ concentration and lipidic environment. We combined solid‐state NMR and …

Sea anemones produce a variety of toxic peptides and proteins, including many ion channel
blockers and modulators, as well as potent cytolysins. This review describes the structures …