Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls

SF Witchel, SE Oberfield, AS Peña - Journal of the Endocrine …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

[HTML][HTML] Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention

O Osibogun, O Ogunmoroti, ED Michos - Trends in cardiovascular …, 2020 - Elsevier
Although polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders
affecting women, its etiology is not entirely understood. Clinical symptoms of PCOS include …

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift

CJ Nolan, M Prentki - Diabetes and Vascular Disease …, 2019 - journals.sagepub.com
While few dispute the existence of the metabolic syndrome as a clustering of factors
indicative of poor metabolic health, its utility above that of its individual components in the …

Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome

X Qu, R Donnelly - International journal of molecular sciences, 2020 - mdpi.com
Human sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver that
binds sex steroids with high affinity and specificity. Clinical observations and reports in the …

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

JA Santos-Marcos, M Mora-Ortiz… - Biology of sex …, 2023 - Springer
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D),
are now a widespread pandemic in the developed world. These pathologies show sex …

Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper

S Palomba - Human Reproduction, 2021 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility;
however, whether women with PCOS and spontaneous or drug-induced ovulatory cycles …

The role of glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome

K Bednarz, K Kowalczyk, M Cwynar, D Czapla… - International journal of …, 2022 - mdpi.com
Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …

Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

X Zhang, W Zhang, Z Wang, N Zheng, F Yuan… - Cell death & …, 2022 - nature.com
In mammals, nonrenewable primordial follicles are activated in an orderly manner to
maintain the longevity of reproductive life. Mammalian target of rapamycin (mTOR)-KIT …

Different kinds of oral contraceptive pills in polycystic ovary syndrome: a systematic review and meta-analysis

M Forslund, J Melin, S Alesi, T Piltonen… - European journal of …, 2023 - academic.oup.com
Objective To compare between different combined oral contraceptive pills (COCPs) as part
of the update of the International Evidence-Based Guidelines on the Assessment and …

Circulating miR-148a-5p and miR-21-5p as novel diagnostic biomarkers in adult Egyptian male patients with metabolic syndrome

AS Doghish, AM Elsisi, AI Amin, AI Abulsoud - Canadian Journal of …, 2021 - Elsevier
Abstract Background Metabolic syndrome (MetS) is a group of abnormalities related to
metabolism that increase the risk of cardiac diseases, type 2 diabetes and mortality …