Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …

Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Antibodies have the capacity to bind a diverse set of antigens, and they have become critical
therapeutics and diagnostic molecules. The binding of antibodies is facilitated by a set of six …

Molecular evolution is an important step in the development of therapeutic antibodies.
However, the current method of affinity maturation is overly costly and labor-intensive …

1Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, USA,
2Department of Chemical and Biomolecular Engineering, Johns Hopkins University …

In response to pathogens, the adaptive immune system generates specific antibodies that
bind and neutralize foreign antigens. Understanding the composition of an individual's …

As an indispensable component of recombinant fusion proteins, linkers have shown
increasing importance in the construction of stable, bioactive fusion proteins. This review …

Successful biologics must satisfy multiple properties including activity and particular
physicochemical features that are globally defined as developability. These multiple …

To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result
in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …

It has been over four decades since the development of monoclonal antibodies (mAbs)
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …