[HTML][HTML] The past, present and future of anti-malarial medicines
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
[HTML][HTML] Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action
Specialized plant terpenoids have found fortuitous uses in medicine due to their
evolutionary and biochemical selection for biological activity in animals. However, these …
evolutionary and biochemical selection for biological activity in animals. However, these …
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
GQ Chen, FA Benthani, J Wu, D Liang… - Cell Death & …, 2020 - nature.com
The antimalarial drug artemisinin and its derivatives have been explored as potential
anticancer agents, but their underlying mechanisms are controversial. In this study, we found …
anticancer agents, but their underlying mechanisms are controversial. In this study, we found …
[HTML][HTML] Antibiotic discovery: where have we come from, where do we go?
B Ribeiro da Cunha, LP Fonseca, CRC Calado - Antibiotics, 2019 - mdpi.com
Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …
Drug repurposing in cancer
L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …
increase in the coming years. Whereas the limited success with current therapies has driven …
[HTML][HTML] Oxidative stress and pathogenesis in malaria
M Vasquez, M Zuniga, A Rodriguez - Frontiers in cellular and …, 2021 - frontiersin.org
Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen
species by host phagocytes is an essential component of the host response to Plasmodium …
species by host phagocytes is an essential component of the host response to Plasmodium …
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
CJ Paddon, JD Keasling - Nature reviews microbiology, 2014 - nature.com
Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …
biology and metabolic engineering, have enabled the engineering of microorganisms to …
[HTML][HTML] A brief history of the antibiotic era: lessons learned and challenges for the future
RI Aminov - Frontiers in microbiology, 2010 - frontiersin.org
This article gives a very brief overview of the antibiotic era, beginning from the discovery of
first antibiotics until the present day situation, which is marred by the emergence of hard-to …
first antibiotics until the present day situation, which is marred by the emergence of hard-to …
[HTML][HTML] Exploring different approaches to improve the success of drug discovery and development projects: a review
GK Kiriiri, PM Njogu, AN Mwangi - Future Journal of Pharmaceutical …, 2020 - Springer
Background There has been a significant increase in the cost and timeline of delivering new
drugs for clinical use over the last three decades. Despite the increased investments in …
drugs for clinical use over the last three decades. Despite the increased investments in …
[HTML][HTML] Antimalarial drug resistance: literature review and activities and findings of the ICEMR network
L Cui, S Mharakurwa, D Ndiaye… - The American journal …, 2015 - ncbi.nlm.nih.gov
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …