Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …

A longitudinal transcriptomic analysis from unfed to post-engorgement midguts of adult female Ixodes scapularis

S Lu, LA Martins, J Kotál, JMC Ribeiro, L Tirloni - Scientific Reports, 2023 - nature.com
The hematophagy behavior has evolved independently several times within the Arthropoda
phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct …

Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

Z Franta, H Frantová, J Konvičková, M Horn, D Sojka… - Parasites & vectors, 2010 - Springer
Background Ticks are vectors of a wide variety of pathogens causing severe diseases in
humans and domestic animals. Intestinal digestion of the host blood is an essential process …

The role of cystatins in tick physiology and blood feeding

A Schwarz, JJ Valdés, M Kotsyfakis - Ticks and tick-borne diseases, 2012 - Elsevier
Ticks, as obligate hematophagous ectoparasites, impact greatly on animal and human
health because they transmit various pathogens worldwide. Over the last decade, several …

Mouthparts and digestive system

DE Sonenshine, JM Anderson, RM Roe - Biology of ticks, 2014 - books.google.com
Ticks are obligate parasites that feed entirely on vertebrate blood. Ticks have evolved novel
methods for acquiring and processing blood; instead of biting their hosts to draw blood …

[HTML][HTML] A multi-omics approach for understanding blood digestion dynamics in Ixodes scapularis and identification of anti-tick vaccine targets

JB Reyes, M McVicar, S Beniwal, A Sharma… - Ticks and Tick-borne …, 2024 - Elsevier
Ixodes scapularis, the black-legged tick, is a major arthropod vector that transmits the
causative agents of Lyme disease and several other pathogens of human significance. The …

IrCL1–The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

Z Franta, D Sojka, H Frantova, J Dvorak, M Horn… - International journal for …, 2011 - Elsevier
Intracellular proteolysis of ingested blood proteins is a crucial physiological process in ticks.
In our model tick, Ixodes ricinus, cathepsin L (IrCL1) is part of a gut-associated multi …

Rhipicephalus microplus cystatin as a potential cross-protective tick vaccine against Rhipicephalus appendiculatus

LF Parizi, CK Rangel, GA Sabadin, BF Saggin… - Ticks and tick-borne …, 2020 - Elsevier
Rhipicephalus appendiculatus, the brown ear tick, is an important disease vector of livestock
in eastern, central and southern Africa. Rhipicephalus appendiculatus acaricide resistance …

A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases

S Lu, LA da Rocha, RJS Torquato, ISV Junior… - Ticks and tick-borne …, 2020 - Elsevier
Rhipicephalus microplus is a cattle ectoparasite found in tropical and subtropical regions
around the world with great impact on livestock production. R. microplus can also harbor …

A novel type I cystatin of parasite origin with atypical legumain-binding domain

J Ilgová, L Jedličková, H Dvořáková, M Benovics… - Scientific Reports, 2017 - nature.com
Parasite inhibitors of cysteine peptidases are known to influence a vast range of processes
linked to a degradation of either the parasites' own proteins or proteins native to their hosts …