Two types of sequences, proline-rich domains (PRDs) and the WASP-homology 2 (WH2)
domain, are found in most actin filament nucleation and elongation factors discovered thus …

Tropomodulins are a family of four proteins (Tmods 1–4) that cap the pointed ends of actin
filaments in actin cytoskeletal structures in a developmentally regulated and tissue‐specific …

Nemaline myopathy (NM) is a genetic muscle disorder characterized by muscle dysfunction
and electron-dense protein accumulations (nemaline bodies) in myofibers. Pathogenic …

Cytoskeletal structures characterized by actin filaments with uniform lengths, including the
thin filaments of striated muscles and the spectrin-based membrane skeleton, use barbed …

Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation
of striated muscle thin filament assembly; its physiological function has yet to be studied. We …

In this chapter, we present the current knowledge on de novo assembly, growth, and
dynamics of striated myofibrils, the functional architectural elements developed in skeletal …

ADF/cofilins drive cytoskeletal dynamics by promoting the disassembly of" aged" ADP-actin
filaments. Mammals express several ADF/cofilin isoforms, but their specific biochemical …

Actin is a highly expressed protein in eukaryotic cells and is essential for numerous cellular
processes. In particular, efficient striated muscle contraction is dependent upon the precise …

The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …

How proteins sharing a common fold have evolved different functions is a fundamental
question in biology. Tropomodulins (Tmods) are prototypical actin filament pointed-end …