Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Overall, 12% of the global population (800 million) suffers from liver disease, which causes 2
million deaths every year. Liver injury involving characteristic reactive oxygen/nitrogen …

Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Aging disrupts the maintenance of liver homeostasis, which impairs hepatocyte regeneration
and aggravates acute liver injury (ALI), ultimately leading to the development of acute liver …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. It is a critical pre-stage condition of severe hepatopathy, characterized by excessive …

Simple Summary During the development of chronic liver disease, the hepatic sinusoid
undergoes major changes that further compromise the hepatic function, inducing persistent …

The liver is not oblivious to the passage of time, as ageing is a major risk factor for the
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …