[HTML][HTML] The broad-spectrum antiviral functions of IFIT and IFITM proteins
MS Diamond, M Farzan - Nature Reviews Immunology, 2013 - nature.com
Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …
The ISG56/IFIT1 Gene Family
V Fensterl, GC Sen - Journal of Interferon & Cytokine Research, 2011 - liebertpub.com
The ISG56/IFIT1 family of genes is clustered on human chromosome 10 and is comprised of
4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are …
4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are …
[HTML][HTML] Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
[HTML][HTML] 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
S Daffis, KJ Szretter, J Schriewer, J Li, S Youn, J Errett… - Nature, 2010 - nature.com
Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated
at the N-7 and 2′-O positions of the 5′ guanosine cap by specific nuclear and cytoplasmic …
at the N-7 and 2′-O positions of the 5′ guanosine cap by specific nuclear and cytoplasmic …
IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
A Pichlmair, C Lassnig, CA Eberle, MW Górna… - Nature …, 2011 - nature.com
Antiviral innate immunity relies on the recognition of microbial structures. One such structure
is viral RNA that carries a triphosphate group on its 5′ terminus (PPP-RNA). By an affinity …
is viral RNA that carries a triphosphate group on its 5′ terminus (PPP-RNA). By an affinity …
[HTML][HTML] IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
T Ohkuri, A Ghosh, A Kosaka, J Zhu, M Ikeura… - Cancer immunology …, 2014 - AACR
Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be
elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment …
elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment …
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs
KI Leonova, L Brodsky, B Lipchick… - Proceedings of the …, 2013 - National Acad Sciences
Large parts of mammalian genomes are transcriptionally inactive and enriched with various
classes of interspersed and tandem repeats. Here we show that the tumor suppressor …
classes of interspersed and tandem repeats. Here we show that the tumor suppressor …
Viral apoptosis is induced by IRF‐3‐mediated activation of Bax
Upon infection with many RNA viruses, the cytoplasmic retinoic acid inducible gene‐I (RIG‐
I) pathway activates the latent transcription factor IRF‐3, causing its nuclear translocation …
I) pathway activates the latent transcription factor IRF‐3, causing its nuclear translocation …
[HTML][HTML] IPS-1 is essential for the control of West Nile virus infection and immunity
The innate immune response is essential for controlling West Nile virus (WNV) infection but
how this response is propagated and regulates adaptive immunity in vivo are not defined …
how this response is propagated and regulates adaptive immunity in vivo are not defined …