Metabolomics for biomarker discovery: moving to the clinic

A Zhang, H Sun, G Yan, P Wang… - Biomed research …, 2015 - Wiley Online Library
To improve the clinical course of diseases, more accurate diagnostic and assessment
methods are required as early as possible. In order to achieve this, metabolomics offers new …

Serum metabolomics as a novel diagnostic approach for disease: a systematic review

A Zhang, H Sun, X Wang - Analytical and bioanalytical chemistry, 2012 - Springer
Metabolomics is a promising “omics” field in systems biology; its objective is comprehensive
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …

[PDF][PDF] A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

P Luo, P Yin, R Hua, Y Tan, Z Li, G Qiu, Z Yin… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …

Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics

Q Huang, Y Tan, P Yin, G Ye, P Gao, X Lu, H Wang… - Cancer research, 2013 - AACR
Hepatocellular carcinoma has a poor prognosis due to its rapid development and early
metastasis. In this report, we characterized the metabolic features of hepatocellular …

New insights into molecules and pathways of cancer metabolism and therapeutic implications

Z Tang, Z Xu, X Zhu, J Zhang - Cancer Communications, 2021 - Wiley Online Library
Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …

The metabolomic window into hepatobiliary disease

D Beyoğlu, JR Idle - Journal of hepatology, 2013 - Elsevier
The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease …

[PDF][PDF] Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma

X Wang, A Zhang, H Sun - Hepatology, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third
most common cause of cancer‐related death worldwide. Incidence remains highest in the …

Mass spectrometry‐based metabolomics: applications to biomarker and metabolic pathway research

A Zhang, H Sun, G Yan, P Wang… - Biomedical …, 2016 - Wiley Online Library
Mass spectrometry‐based metabolomics has become increasingly popular in molecular
medicine. High‐definition mass spectrometry (MS), coupled with pattern recognition …

Function, detection and alteration of acylcarnitine metabolism in hepatocellular carcinoma

S Li, D Gao, Y Jiang - Metabolites, 2019 - mdpi.com
Acylcarnitines play an essential role in regulating the balance of intracellular sugar and lipid
metabolism. They serve as carriers to transport activated long-chain fatty acids into …

Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment

A Zhang, H Sun, X Wang - Applied biochemistry and biotechnology, 2012 - Springer
Metabolomics is the systematic study of the unique chemical fingerprints of low molecular
weight endogenous metabolites or metabolite profiles in a biological sample. Metabolites …