Metabolomics for biomarker discovery: moving to the clinic
A Zhang, H Sun, G Yan, P Wang… - Biomed research …, 2015 - Wiley Online Library
To improve the clinical course of diseases, more accurate diagnostic and assessment
methods are required as early as possible. In order to achieve this, metabolomics offers new …
methods are required as early as possible. In order to achieve this, metabolomics offers new …
Serum metabolomics as a novel diagnostic approach for disease: a systematic review
A Zhang, H Sun, X Wang - Analytical and bioanalytical chemistry, 2012 - Springer
Metabolomics is a promising “omics” field in systems biology; its objective is comprehensive
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …
[PDF][PDF] A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma
P Luo, P Yin, R Hua, Y Tan, Z Li, G Qiu, Z Yin… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …
effective biomarkers for the early detection of HCC results in unsatisfactory curative …
Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics
Q Huang, Y Tan, P Yin, G Ye, P Gao, X Lu, H Wang… - Cancer research, 2013 - AACR
Hepatocellular carcinoma has a poor prognosis due to its rapid development and early
metastasis. In this report, we characterized the metabolic features of hepatocellular …
metastasis. In this report, we characterized the metabolic features of hepatocellular …
New insights into molecules and pathways of cancer metabolism and therapeutic implications
Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …
characterized by unlimited proliferation, transformation and migration, and can destroy …
The metabolomic window into hepatobiliary disease
The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease …
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease …
[PDF][PDF] Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma
X Wang, A Zhang, H Sun - Hepatology, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third
most common cause of cancer‐related death worldwide. Incidence remains highest in the …
most common cause of cancer‐related death worldwide. Incidence remains highest in the …
Mass spectrometry‐based metabolomics: applications to biomarker and metabolic pathway research
A Zhang, H Sun, G Yan, P Wang… - Biomedical …, 2016 - Wiley Online Library
Mass spectrometry‐based metabolomics has become increasingly popular in molecular
medicine. High‐definition mass spectrometry (MS), coupled with pattern recognition …
medicine. High‐definition mass spectrometry (MS), coupled with pattern recognition …
Function, detection and alteration of acylcarnitine metabolism in hepatocellular carcinoma
S Li, D Gao, Y Jiang - Metabolites, 2019 - mdpi.com
Acylcarnitines play an essential role in regulating the balance of intracellular sugar and lipid
metabolism. They serve as carriers to transport activated long-chain fatty acids into …
metabolism. They serve as carriers to transport activated long-chain fatty acids into …
Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment
A Zhang, H Sun, X Wang - Applied biochemistry and biotechnology, 2012 - Springer
Metabolomics is the systematic study of the unique chemical fingerprints of low molecular
weight endogenous metabolites or metabolite profiles in a biological sample. Metabolites …
weight endogenous metabolites or metabolite profiles in a biological sample. Metabolites …