[HTML][HTML] Enteric neuroimmune interactions coordinate intestinal responses in health and disease

H Wang, JPP Foong, NL Harris, JC Bornstein - Mucosal immunology, 2022 - Elsevier
The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local
immune system bidirectionally. Recent publications have demonstrated that such …

Microbiota modulate sympathetic neurons via a gut–brain circuit

PA Muller, M Schneeberger, F Matheis, P Wang… - Nature, 2020 - nature.com
Connections between the gut and brain monitor the intestinal tissue and its microbial and
dietary content, regulating both physiological intestinal functions such as nutrient absorption …

[HTML][HTML] The role of intestinal macrophages in gastrointestinal homeostasis: heterogeneity and implications in disease

JLK Yip, GK Balasuriya, SJ Spencer… - Cellular and molecular …, 2021 - Elsevier
Intestinal macrophages play a key role in the gut immune system and the regulation of
gastrointestinal physiology, including gut motility and secretion. Their ability to keep the gut …

Endogenous glutamate excites myenteric calbindin neurons by activating group I metabotropic glutamate receptors in the mouse colon

M Swaminathan, EL Hill-Yardin, JC Bornstein… - Frontiers in …, 2019 - frontiersin.org
Glutamate is a classic excitatory neurotransmitter in the central nervous system (CNS), but
despite several studies reporting the expression of glutamate together with its various …

Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons

H Wang, K Barry, A Zaini, G Coakley, M Moyat… - PLoS …, 2024 - journals.plos.org
Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and
sweep'response characterised by increased mucus secretion and intestinal hypermotility …

Evaluation of myenteric neurons in the colon of rats exposed to 2, 4 dichlorophenoxyacetic acid herbicide

W Nanni, GS Porto, JNB Pereira… - … Science and Health …, 2022 - Taylor & Francis
The assessment of the enteric nervous system provides a better understanding of the effects
that contaminants can have on the health and well-being of organisms. It has been reported …

Synaptic Components, Function and Modulation Characterized by GCaMP6f Ca2+ Imaging in Mouse Cholinergic Myenteric Ganglion Neurons

JF Margiotta, KM Smith-Edwards… - Frontiers in …, 2021 - frontiersin.org
The peristaltic contraction and relaxation of intestinal circular and longitudinal smooth
muscles is controlled by synaptic circuit elements that impinge upon phenotypically diverse …

Carbohydrates: Binding Sites and Potential Drug Targets for Neural-Affecting Pathogens

CL Schengrund - Glycobiology of the Nervous System, 2022 - Springer
A number of viruses that have caused wide spread concern eg Ebola, Zika, and SARS-CoV2
(severe acute respiratory syndrome coronavirus 2 also known as COVID 19) have at various …

[HTML][HTML] Peripheral neuronal activation shapes the microbiome and alters gut physiology

JA Griffiths, BB Yoo, P Thuy-Boun, VJ Cantu… - Cell reports, 2024 - cell.com
The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system
(ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI …

Co-treatment with BGP-15 exacerbates 5-fluorouracil-induced gastrointestinal dysfunction

RM McQuade, M Al Thaalibi, AC Petersen… - Frontiers in …, 2019 - frontiersin.org
Gastrointestinal (GI) side-effects of chemotherapy present a constant impediment to efficient
and tolerable treatment of cancer. GI symptoms often lead to dose reduction, delays and …