The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

[HTML][HTML] Mitochondria and cardiovascular diseases—from pathophysiology to treatment

G Siasos, V Tsigkou, M Kosmopoulos… - Annals of …, 2018 - ncbi.nlm.nih.gov
Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Effects of Aerobic Training and Curcumin Supplementation on Cardiomyocyte Apoptosis and MiRNAs Expression in Rats Exposed to Arsenic

A Majidi, R Poozesh Jadidi, MAR Nourazar… - Sport …, 2020 - spj.ssrc.ac.ir
The aim of this study was to investigate the effects of HIIT and curcumin supplementation on
cardiac tissue caspase 3 content and also expression of miR-1 and miR-133 in rats exposed …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

Targeting mitochondrial fusion and fission proteins for cardioprotection

S Hernandez‐Resendiz, F Prunier… - Journal of Cellular …, 2020 - Wiley Online Library
New treatments are needed to protect the myocardium against the detrimental effects of
acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in …

PGC-1: the energetic regulator in cardiac metabolism

W Di, J Lv, S Jiang, C Lu, Z Yang, Z Ma, W Hu… - Current issues in …, 2018 - mdpi.com
The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can
induce the expression of several downstream genes that play pivotal roles in the regulation …

Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology

SM Adaniya, J O-Uchi, MW Cypress… - … of Physiology-Cell …, 2019 - journals.physiology.org
Mitochondrial fragmentation frequently occurs in chronic pathological conditions as seen in
various human diseases. In fact, abnormal mitochondrial morphology and mitochondrial …

Cardiomyocyte mitochondrial dynamics in health and disease and the role of exercise training: A brief review

B Ebadi, A Damirchi, KA Alamdari… - Research in …, 2018 - journals.lww.com
Mitochondria as dynamic organelle constantly undergo fusion and fission reactions, leading
to continuous reconstruction of the mitochondrial network for elongated or fragmentation …

What and how can physical activity prevention function on Parkinson's disease?

B Fan, R Jabeen, B Bo, C Guo, M Han… - Oxidative medicine …, 2020 - Wiley Online Library
Aim. This study was aimed at investigating the effects and molecular mechanisms of
physical activity intervention on Parkinson's disease (PD) and providing theoretical …

Exercise training enhances myocardial mitophagy and improves cardiac function via Irisin/FNDC5-PINK1/Parkin pathway in MI mice

H Li, S Qin, Q Liang, Y Xi, W Bo, M Cai, Z Tian - Biomedicines, 2021 - mdpi.com
Myocardial infarction is the major cause of death in cardiovascular disease. In vitro and in
vivo models are used to find the exercise mode which has the most significant effect on …