Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Progress and challenges in targeting the SARS-CoV-2 papain-like protease

H Tan, Y Hu, P Jadhav, B Tan… - Journal of medicinal …, 2022 - ACS Publications
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …

The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022

X Pang, W Xu, Y Liu, H Li, L Chen - European Journal of Medicinal …, 2023 - Elsevier
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …

Inhibitors of sars-cov-2 plpro

DJ Calleja, G Lessene, D Komander - Frontiers in chemistry, 2022 - frontiersin.org
The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …

A comprehensive study on the adsorption, corrosion inhibition efficiency and stability of acriflavine on mild steel in 1 M HCl solution

R Solmaz, A Salcı, YA Dursun, G Kardaş - Colloids and Surfaces A …, 2023 - Elsevier
A comprehensive study was conducted on the adsorption, corrosion inhibition efficiency and
stability of acriflavine (ACF) on mild steel (MS) in 1 M HCl solution. Electrochemical studies …

Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Targeting SARS-CoV-2 papain-like protease in the postvaccine era

AT Ton, M Pandey, JR Smith, F Ban… - Trends in …, 2022 - cell.com
While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …

Acriflavine, an acridine derivative for biomedical application: current state of the art

K Piorecka, J Kurjata, WA Stanczyk - Journal of Medicinal …, 2022 - ACS Publications
Acriflavine (ACF) has been known for years as an antibacterial drug. The identification of key
oncogenic mechanisms has brought, in recent years, a significant increase in studies on …

Deuterated drugs and biomarkers in the COVID-19 pandemic

RD Jansen-van Vuuren, L Jedlovčnik, J Košmrlj… - ACS …, 2022 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan …

Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery

X Li, Y Song - Drug Discovery Today, 2024 - Elsevier
As a highly contagious human pathogen, severe acute respiratory syndrome-associated
coronavirus-2 (SARS-CoV-2) has infected billions of people worldwide with more than 6 …