About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell
(SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome …

Genetically triggered thoracic aortic aneurysms (TAAs) are usually considered to exhibit
minimal levels of inflammation. However, emerging data demonstrate that specific features …

Fibrillin-1 is an extracellular matrix protein that assembles into microfibrils which provide
critical functions in large blood vessels and other tissues. Mutations in the fibrillin-1 gene are …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

β-Blockers, eg, atenolol, are the cornerstone therapy for thoracic aortic aneurysm (TAA) in
patients with Marfan syndrome; however, continued aortic dilatation has been reported. We …

Marfan syndrome (MFS) is characterized by the formation of ascending aortic aneurysms
resulting from altered assembly of extracellular matrix fibrillin-containing microfibrils and …

Marfan syndrome (MFS) is a genetic disorder that affects multiple organs. Mortality imposed
by aortic aneurysm and dissections represent the most serious clinical manifestation of MFS …

Connective tissue is known to provide structural and functional “glue” properties to other
tissues. It contains cellular and molecular components that are arranged in several dynamic …

Thoracic aortic disease affects people of all ages and the majority of those aged< 60 years
have an underlying genetic cause. There is presently no effective medical therapy for …