Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …

T cell differentiation is a highly regulated, multi-step process necessary for the progressive
establishment of effector functions, immunological memory, and long-term control of …

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …

Tumors employ diverse strategies for immune evasion. Unraveling the mechanisms by
which tumors suppress anti-tumor immunity facilitates the development of immunotherapies …

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in
tumor cells, resulting in a tumor microenvironment (TME) characterized by accumulation of …

The efficacy of radiotherapy (RT) is limited by inefficient X‐ray absorption and reactive
oxygen species generation, upregulation of immunosuppressive factors, and a reducing …

Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms
underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …