Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant
interest based on its agricultural and medical applications, which range from use as a fodder …

Peptides fulfill a plethora of functions in plant growth, development, and stress responses.
They act as key components of cell-to-cell communication, interfere with signaling and …

Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as
pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive …

Many bioactive plant cyclic peptides form side-chain-derived macrocycles. Lyciumins, cyclic
plant peptides with tryptophan macrocyclizations, are ribosomal peptides (RiPPs) originating …

Asparaginyl endopeptidases (AEPs) are proteases that have crucial roles in plant defense
and seed storage protein maturation. Select plant AEPs, however, do not function as …

Bowman-Birk inhibitors (BBIs) are found primarily in seeds of legumes and in cereal grains.
These canonical inhibitors share a highly conserved nine-amino acids binding loop motif …

Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the
biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs …