MS/MS-based molecular networking: an efficient approach for natural products Dereplication

GF Qin, X Zhang, F Zhu, ZQ Huo, QQ Yao, Q Feng… - Molecules, 2022 - mdpi.com
Natural products (NPs) have historically played a primary role in the discovery of small-
molecule drugs. However, due to the advent of other methodologies and the drawbacks of …

Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study

EJC de Blanco, EM Addo, HL Rakotondraibe… - Natural Product …, 2023 - pubs.rsc.org
Covering up to early 2023 The present review summarizes recent accomplishments made
as part of a multidisciplinary, multi-institutional anticancer drug discovery project, wherein …

Polypharmacology-Labeled Molecular Networking: An Analytical Technology Workflow for Accelerated Identification of Multiple Bioactive Constituents in Complex …

Y Zhao, O Gericke, T Li, L Kjaerulff… - Analytical …, 2023 - ACS Publications
Discovery of sustainable and benign-by-design drugs to combat emerging health
pandemics calls for new analytical technologies to explore the chemical and …

A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling in Melanoma Cells

L Durr, JK Reinhardt, M Dobrzynski, T Hell… - Journal of natural …, 2022 - ACS Publications
A library of more than 2500 plant extracts was screened for activity on oncogenic signaling
in melanoma cells. The ethyl acetate extract from the aerial parts of Artemisia argyi …

[PDF][PDF] 六神曲化学成分及抗氧化活性研究

李虹霞, 朱月健, 尹磊, 崔微, 张希… - 中成药, 2023 - pmt5b327c-pic7.websiteonline.cn
六神曲化学成分及抗氧化活性研究 Page 1 [成分分析] 六神曲化学成分及抗氧化活性研究 李虹霞
1, 朱月健2, 尹磊2, 崔微1, 张希1, 许枬1∗ (1. 辽宁中医药大学药学院, 辽宁大连116600; 2. 安徽普 …

Advanced technologies targeting isolation and characterization of natural products

SH Dong, ZK Duan, M Bai, XX Huang… - TrAC Trends in Analytical …, 2024 - Elsevier
Natural products (NPs), are small molecules produced naturally by any organism. As they
may be isolated in small quantities, having interesting biological activities and lush chemical …

[HTML][HTML] Flavonoids from Ericameria nauseosa inhibiting PI3K/AKT pathway in human melanoma cells

T Hell, M Dobrzyński, F Gröflin, JK Reinhardt… - Biomedicine & …, 2022 - Elsevier
Abstract The PI3K/AKT and MAPK/ERK pathways are frequently mutated in metastatic
melanoma. In a screen of over 2500 plant extracts, the dichloromethane extract of …

Nucleobase-Coupled Xanthones with Anti-ROS Effects from Marine-Derived Fungus Aspergillus sydowii

R Ge, X Guo, H Jia, J Zhang, A Fan, D Liu… - The Journal of …, 2024 - ACS Publications
A MS/MS-based molecular networking approach compared to the Global Natural Product
Social Molecular Networking library, in association with genomic annotation of natural …

Activity labelled molecular networking fuels the antioxidation active molecules profile of Ginger

Q Wang, T Chen, M La, Z Song, M Gao, T Yang, Y Li… - Food Chemistry, 2023 - Elsevier
Ginger has been used as consumed food spice and folk medicine in daily life for thousands
of years in various regions of the world. Considerable antioxidation is one of the major …

Exploring bixin from Bixa orellana L. seeds: quantification and in silico insights into its anti-cancer potential

K Muthusamy, G Ramasamy, C Ravikumar… - Journal of …, 2023 - Taylor & Francis
Bixin, the key pigment of Bixa orellana L., is an apo-carotenoid found in the seed arils. The
present study aimed to quantitatively determine the bixin content of seeds and explore its …