Practical aspects of microRNA target prediction

T M. Witkos, E Koscianska… - Current molecular …, 2011 - benthamdirect.com
microRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at
the posttranscriptional level. These small regulatory molecules play a key role in the majority …

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid

P Takousis, A Sadlon, J Schulz, I Wohlers… - Alzheimer's & …, 2019 - Elsevier
Abstract Introduction Several microRNAs (miRNAs) have been implicated in Alzheimer's
disease pathogenesis, but the evidence from individual case-control studies remains …

Exosomal cell-to-cell transmission of alpha synuclein oligomers

KM Danzer, LR Kranich, WP Ruf… - Molecular …, 2012 - Springer
Background Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of
sporadic and familial Parkinson's disease (PD) as well as dementia with Lewy bodies, with …

[HTML][HTML] Identification of blood microRNAs associated to Parkinsońs disease

R Margis, R Margis, CRM Rieder - Journal of biotechnology, 2011 - Elsevier
The present study demonstrates that blood samples can be used as a source of miRNA
identification associated to Parkinson's disease (PD). A set of six differentially expressed …

microRNA-based biomarkers in Alzheimer's disease (AD)

Y Zhao, V Jaber, PN Alexandrov, A Vergallo… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized
by complex pathophysiological dynamics taking place at multiple biological levels, including …

Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases

S Ghimire, L Subedi, N Acharya… - Journal of agricultural …, 2021 - ACS Publications
Moringa oleifera, popularly known as a miracle tree or tree of life, has been extensively used
as a functional food and nutritional asset worldwide. Ethnomedicinal and traditional uses of …

Impaired neurosteroid synthesis in multiple sclerosis

F Noorbakhsh, KK Ellestad, F Maingat, KG Warren… - Brain, 2011 - academic.oup.com
High-throughput technologies have led to advances in the recognition of disease pathways
and their underlying mechanisms. To investigate the impact of micro-RNAs on the disease …

[HTML][HTML] Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

RR Singh, I Mondal, T Janjua, A Popat… - Bioactive Materials, 2024 - Elsevier
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that
remains incurable despite the multitude of improvements in cancer therapeutics. The …

Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2

Y Miyazaki, H Adachi, M Katsuno, M Minamiyama… - Nature medicine, 2012 - nature.com
Spinal and bulbar muscular atrophy (SBMA) is an inherited neurodegenerative disorder
caused by the expansion of the polyglutamine (polyQ) tract of the androgen receptor (AR …

Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice

R Roshan, S Shridhar, MA Sarangdhar, A Banik… - Rna, 2014 - rnajournal.cshlp.org
Several microRNAs have been implicated in neurogenesis, neuronal differentiation,
neurodevelopment, and memory. Development of miRNA-based therapeutics, however …