Importin‐β family proteins (Imp‐βs) are nucleocytoplasmic transport receptors (NTRs) that
import and export proteins and RNAs through the nuclear pores. The family consists of 14 …

Cytoplasmic elongation of the poly (A) tail was originally identified as a mechanism to
activate maternal mRNAs, stored as silent transcripts with short poly (A) tails, during meiotic …

Oxidative stress can alter the expression level of many microRNAs (miRNAs), but how these
changes are integrated and related to oxidative stress responses is poorly understood. In …

Microsatellite expansions are the leading cause of numerous neurodegenerative disorders.
Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with …

Pathological cardiac hypertrophy leads to heart failure (HF). The ubiquitin-proteasome
system (UPS) plays a key role in maintaining protein homeostasis and cardiac function …

Tissue-specific alternative splicing is critical for the emergence of tissue identity during
development, yet the role of this process in malignant transformation is undefined. Tissue …

Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a sequence-specific
RNA-binding protein. We had reported that CPEB3 is involved in hepatocellular carcinoma …

Long-term memory requires activity-dependent synthesis of plasticity-related proteins
(PRPs) to strengthen synaptic efficacy and consequently consolidate memory. Cytoplasmic …

Background Hepatocellular carcinoma (HCC) is one of the most aggressive malignant
tumors, with a poor long-term prognosis worldwide. The functional deregulations of global …

Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here,
we build a compendium of 2218 primary tumours across 12 human cancer types and …