Organ morphogenesis is a complex process coordinated by cell specification, epithelial–
mesenchymal interactions and tissue polarity. A striking example is the pattern of regularly …

Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of
adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon …

The control of cell fate through oriented cell division is imperative for proper organ
development. Basal epidermal progenitor cells divide parallel or perpendicular to the …

Tensional homeostasis is crucial for organ and tissue development, including the
establishment of morphological and functional properties. Skin plays essential roles in …

Physical processes ultimately shape tissue during development. Two emerging proposals
are that cells migrate toward stiffer tissue (durotaxis) and that the extent of cell …

Adult mammalian lungs exhibit a fractal pattern, as each successive generation of airways is
a fraction of the size of the parental branch. Achieving this structure likely requires precise …

To orchestrate collective polarization across tissues, planar cell polarity (PCP) proteins
localize asymmetrically to cell junctions, a conserved feature of PCP that requires the …

Nascent proteins destined for the cell membrane and the secretory pathway are targeted to
the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal …

ASXL1 (additional sex combs–like 1) plays key roles in epigenetic regulation of early
developmental gene expression. De novo protein-truncating mutations in ASXL1 cause …

The orientation of mouse hair follicles is controlled by the planar cell polarity (PCP) pathway.
Mutations in PCP genes result in two categories of hair mis-orientation phenotype: randomly …