Clusterin: a forgotten player in Alzheimer's disease

T Nuutinen, T Suuronen, A Kauppinen… - Brain research reviews, 2009 - Elsevier
Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains
several amphipathic and coiled-coil α-helices, typical characteristics of small heat shock …

Small heat shock proteins in cancer therapy and prognosis

A Zoubeidi, M Gleave - The international journal of biochemistry & cell …, 2012 - Elsevier
Hsp27 and clusterin (CLU are stress-activated small heat shock proteins that are up-
regulated in many cancers where they play important roles in stress-induced protein …

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

R Navab, D Strumpf, B Bandarchi… - Proceedings of the …, 2011 - National Acad Sciences
The tumor microenvironment strongly influences cancer development, progression, and
metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and …

Clusterin as a therapeutic target

MR Wilson, A Zoubeidi - Expert opinion on therapeutic targets, 2017 - Taylor & Francis
Introduction: Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone,
normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers …

The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy

JT Yu, L Tan - Molecular neurobiology, 2012 - Springer
Genetic variation in clusterin gene, also known as apolipoprotein J, has been associated
with Alzheimer's disease (AD) through replicated genome-wide studies, and plasma …

Clusterin mediates TGF-β–induced epithelial–mesenchymal transition and metastasis via Twist1 in prostate cancer cells

M Shiota, A Zardan, A Takeuchi, M Kumano, E Beraldi… - Cancer research, 2012 - AACR
TGF-β promotes epithelial–mesenchymal transition (EMT) and induces clusterin (CLU)
expression, linking these genes to cancer metastasis. CLU is a pleiotropic molecular …

TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells

V Santarlasci, L Maggi, M Capone… - European journal of …, 2009 - Wiley Online Library
Human Th17 clones and circulating Th17 cells showed lower susceptibility to the anti‐
proliferative effect of TGF‐β than Th1 and Th2 clones or circulating Th1‐oriented T cells …

The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases

S Park, KW Mathis, IK Lee - Reviews in Endocrine and Metabolic Disorders, 2014 - Springer
Several isoforms of apolipoprotein J/clusterin (CLU) are encoded from a single gene located
on chromosome 8 in humans. These isoforms are ubiquitously expressed in the tissues, and …

Targeting heat shock proteins in metastatic castration-resistant prostate cancer

AA Azad, A Zoubeidi, ME Gleave, KN Chi - Nature Reviews Urology, 2015 - nature.com
The survival of malignant cells is constantly threatened by a myriad of cellular insults. In the
context of such proteotoxic stress, cancer cells activate cytoprotective adaptive pathways …

Silver nanoparticles/chitosan oligosaccharide/poly (vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway

C Li, Q Wang, J Li, M Hu, S Shi, Z Li, G Wu… - International Journal …, 2016 - Taylor & Francis
Wound healing occupies a remarkable place in everyday pathology and remains a
challenging clinical problem. In our previous study, we prepared a silver …