TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective

M Kapoor, S Chinnathambi - Journal of Neuroinflammation, 2023 - Springer
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Vitamin D in neurological diseases

D Plantone, G Primiano, C Manco, S Locci… - International journal of …, 2022 - mdpi.com
Vitamin D may have multiple effects on the nervous system and its deficiency can represent
a possible risk factor for the development of many neurological diseases. Recent studies are …

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

S Janelidze, E Stomrud, R Smith, S Palmqvist… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established
biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain …

[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Y Yan, X Wang, D Chaput, MK Shin, Y Koh, L Gan… - Cell, 2022 - cell.com
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Advances of zebrafish in neurodegenerative disease: from models to drug discovery

X Wang, JB Zhang, KJ He, F Wang… - Frontiers in Pharmacology, 2021 - frontiersin.org
Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease

T Dubey, S Chinnathambi - Archives of biochemistry and biophysics, 2019 - Elsevier
Ayurveda is the medicinal science, dealing with utilization of naturally available plant
products for treatment. A wide variety of neuroprotective herbs have been reported in …

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia

R Das, AA Balmik, S Chinnathambi - Journal of neuroinflammation, 2020 - Springer
Background Alzheimer's disease is associated with the accumulation of intracellular Tau
tangles within neurons and extracellular amyloid-β plaques in the brain parenchyma, which …

Role of tau in various tauopathies, treatment approaches, and emerging role of nanotechnology in neurodegenerative disorders

P Kaur, A Khera, HK Alajangi, A Sharma… - Molecular …, 2023 - Springer
A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …

Insulin resistance at the crossroad of Alzheimer disease pathology: A review

J Berlanga-Acosta, G Guillén-Nieto… - Frontiers in …, 2020 - frontiersin.org
Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …

Role of dietary fatty acids in microglial polarization in Alzheimer's disease

SE Desale, S Chinnathambi - Journal of neuroinflammation, 2020 - Springer
Microglial polarization is an utmost important phenomenon in Alzheimer's disease that
influences the brain environment. Polarization depends upon the types of responses that …