Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …

Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …

The main receptors for amyloid-beta peptide (Aβ) transport across the blood-brain barrier
(BBB) from brain to blood and blood to brain are low-density lipoprotein receptor related …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

J. Neurochem.(2010) 115, 1077–1089. Abstract Low‐density lipoprotein receptor‐related
protein‐1 (LRP1), a member of the low‐density lipoprotein receptor family, has major roles …

In Alzheimer's disease (AD), pathological forms of tau are transferred from cell to cell and"
seed" aggregation of cytoplasmic tau. Phosphorylation of tau plays a key role in …

Nanotechnology is an area of growing public interest. Its attractiveness stems from the
promise offered socially and economically by the recent significant advances in …

Low-density lipoprotein receptor-related protein-1 (LRP1) is the main cell surface receptor
involved in brain and systemic clearance of the Alzheimer's disease (AD) toxin amyloid-beta …

The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD)
pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature …