Into rather unexplored terrain—Transcellular transport across the blood–brain barrier

M De Bock, V Van Haver, RE Vandenbroucke… - Glia, 2016 - Wiley Online Library
Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …

Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema

M Wahl, A Unterberg, A Baethmann… - Journal of Cerebral …, 1988 - journals.sagepub.com
The characteristics and mechanisms enabling the blood-brain barrier (BBB) to maintain the
milieu of the brain have been reviewed in detail elsewhere (Banks and Kastin, 1987; …

Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey

BJ Balin, RD Broadwell, M Salcman… - Journal of …, 1986 - Wiley Online Library
Pathways traversed by peripherally administered protein tracers for entry to the mammalian
brain were investigated by light and electron microscopy. Native horseradish peroxidase …

Morphometric analysis of CNS microvascular endothelium

BL Coomber, PA Stewart - Microvascular research, 1985 - Elsevier
The ultrastructural features that are critical to the efficient functioning of the blood-brain
barrier (b-bb) were quantified in typical barrier vessels, ie, cerebral gray and white matter …

Gelatinase B modulates selective opening of the blood-brain barrier during inflammation

S Mun-Bryce, GA Rosenberg - American Journal of …, 1998 - journals.physiology.org
Matrix metalloproteinases (MMPs) are associated with neuroinflammatory diseases, and
blood-brain barrier damage is a pathophysiological consequence of central nervous system …

Permeability of blood-brain barrier to various sized molecules

WG Mayhan, DD Heistad - American Journal of Physiology …, 1985 - journals.physiology.org
We studied disruption of the blood-brain barrier (BBB) by acute hypertension and a
hyperosmolar solution. The goals were to determine whether 1) disruption of the BBB occurs …

Molecular pathogenesis of blood–brain barrier breakdown in acute brain injury

S Nag, A Kapadia, DJ Stewart - Neuropathology and applied …, 2011 - Wiley Online Library
S. Nag, A. Kapadia and DJ Stewart (2011) Neuropathology and Applied Neurobiology37, 3–
23 Molecular pathogenesis of blood–brain barrier breakdown in acute brain injury …

Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the …

N Sheikov, N McDannold, F Jolesz, YZ Zhang… - Ultrasound in medicine …, 2006 - Elsevier
Previously, activation of vesicular transport in the brain microvasculature was shown to be
one of the mechanisms of focused ultrasound-induced blood-brain barrier (BBB) opening. In …

Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers

L Hillmer, EB Erhardt, A Caprihan… - Journal of Cerebral …, 2023 - journals.sagepub.com
Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in
cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI) …

Regulation of blood–brain barrier permeability

WG Mayhan - Microcirculation, 2001 - Taylor & Francis
The blood–brain barrier minimizes the entry of molecules into brain tissue. This restriction
arises by the presence of tight junctions (zonulae occludens) between adjacent endothelial …