Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among
which the function of GSDMC has not been clearly described. Herein, we demonstrate that …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …