Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research

TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

DS Skiba, R Nosalski, TP Mikolajczyk… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Inflammation plays a key role in atherosclerosis. The protective
role of angiotensin 1–7 (Ang‐(1–7)) in vascular pathologies suggested the therapeutic use …

[HTML][HTML] The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

SS Karnik, KD Singh, K Tirupula… - British journal of …, 2017 - Wiley Online Library
Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

[HTML][HTML] Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis

I Zaidan, LP Tavares, MA Sugimoto, KM Lima… - JCI insight, 2022 - ncbi.nlm.nih.gov
Nonphlogistic migration of macrophages contributes to the clearance of pathogens and
apoptotic cells, a critical step for the resolution of inflammation and return to homeostasis …

Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications

L Ning, J Rong, Z Zhang, Y Xu - Pharmacological Research, 2021 - Elsevier
Sepsis, caused by the inappropriate host response to infection, is characterized by
excessive inflammatory response and organ dysfunction, thus becomes a critical clinical …

Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: Effects of increasing M2 macrophages

S Navaneethabalakrishnan, BL Goodlett… - Clinical …, 2024 - portlandpress.com
Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and
inflammatory responses, leading to inflammation-associated lymphangiogenesis and …

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

O Razi, AM Teixeira, B Tartibian, N Zamani… - Molecular and cellular …, 2023 - Springer
Abstract Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is
characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems …

[HTML][HTML] Lipid dynamics in LPS-induced neuroinflammation by DESI-MS imaging

OC Oliveira-Lima, J Carvalho-Tavares… - Brain, Behavior, and …, 2019 - Elsevier
It is well-established that bacterial lipopolysaccharides (LPS) can promote
neuroinflammation through receptor Toll-like 4 activation and induces sickness behavior in …