Abstract Purpose of Review Hematopoietic stem cells (HSCs) maintain blood and immune
cell homeostasis by balancing quiescence, self-renewal, and differentiation. HSCs can be …

Local invasion and distant metastasis are the key hallmarks in the aggressive progression of
malignant tumors, including the ability of cancer cells to detach from the extracellular matrix …

Transcription factors (TFs) are proteins that affect gene expression by binding to regulatory
regions of DNA in a sequence specific manner. The binding of TFs to DNA is controlled by …

IL-17–producing Th17 cells are implicated in the pathogenesis of rheumatoid arthritis (RA)
and TNF-α, a proinflammatory cytokine in the rheumatoid joint, facilitates Th17 …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
causative agent of coronavirus disease 19 (COVID-19) that was emerged as a new member …

Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and
its long-term integrity. Although regulation of stress responses incurred as a result of HSC …

Sickle cell disease is a devastating blood disorder that originates from a single point
mutation in the HBB gene coding for hemoglobin. Here, we develop a GMP-compatible …

Lentiviral vectors (LVs) are used for delivery of genes into hematopoietic stem and
progenitor cells (HSPCs) in clinical trials worldwide. LVs, in contrast to retroviral vectors, are …

Previous bulk RNA sequencing or whole genome sequencing on clear cell renal cell
carcinoma (ccRCC) subtyping mainly focused on ccRCC cell origin or the complex tumor …

Neural progenitor cells (NPCs, also known as radial glial progenitors) produce neurons and
then glial cells such as astrocytes during development of the mouse neocortex. Given that …