The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been …

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients
respond well to therapy, others do not, and thus more precise, individualized treatment …

Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional
conversion between tumor-initiating stem cells and nonstem cells triggered by an …

Colorectal carcinoma is one of the most common cancers and one of the leading causes of
cancer-related death in the United States. Pathologic examination of biopsy, polypectomy …

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has
been proposed to identify quiescent and tumor growth–sustaining stem cells. DCLK1+ tuft …

Bmi1 plays an essential part in the self-renewal of hematopoietic and neural stem cells. To
investigate its role in other adult stem cell populations, we generated a mouse expressing a …

Colorectal cancer (CRC) results from the progressive accumulation of genetic and
epigenetic alterations that lead to the transformation of normal colonic mucosa to …