Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
The role of calmodulin in tumor cell migration, invasiveness, and metastasis
A Villalobo, MW Berchtold - International Journal of Molecular Sciences, 2020 - mdpi.com
Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …
binding to target proteins transduces signals encoded by global or subcellular-specific …
Oncogenic Ras isoforms signaling specificity at the membrane
R Nussinov, CJ Tsai, H Jang - Cancer research, 2018 - AACR
How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …
TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis
Y Sun, C Ye, W Tian, W Ye, YY Gao, YD Feng… - Oncogenesis, 2021 - nature.com
Transient receptor potential canonical (TRPC) channels are the most prominent
nonselective cation channels involved in various diseases. However, the function, clinical …
nonselective cation channels involved in various diseases. However, the function, clinical …
[HTML][HTML] TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease
Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
X He, S Li, B Liu, S Susperreguy… - Proceedings of the …, 2017 - National Acad Sciences
The injury phase after myocardial infarcts occurs during reperfusion and is a consequence
of calcium release from internal stores combined with calcium entry, leading to cell death by …
of calcium release from internal stores combined with calcium entry, leading to cell death by …
[HTML][HTML] Reprint of: Mechanosensitive ion channels in cell migration
BC Coutino, R Mayor - Cells & development, 2021 - Elsevier
Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …
forces. Cell membrane mechanosensors represent the first step towards the conversion of …
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation–implications in atherosclerosis
Objective: The mechanisms involved in NOX5 activation in atherosclerotic processes are not
completely understood. The present study tested the hypothesis that …
completely understood. The present study tested the hypothesis that …
Calmodulin and PI3K signaling in KRAS cancers
R Nussinov, G Wang, CJ Tsai, H Jang, S Lu… - Trends in cancer, 2017 - cell.com
Calmodulin (CaM) uniquely promotes signaling by oncogenic K-Ras, but not by N-Ras or H-
Ras. How CaM interacts with K-Ras and how this stimulates cell proliferation are among the …
Ras. How CaM interacts with K-Ras and how this stimulates cell proliferation are among the …
[PDF][PDF] Phosphorylated calmodulin promotes PI3K activation by binding to the SH2 domains
M Zhang, H Jang, V Gaponenko, R Nussinov - Biophysical Journal, 2017 - cell.com
How calmodulin (CaM) acts in KRAS-driven cancers is a vastly important question. CaM
binds to and stimulates PI3Kα/Akt signaling, promoting cell growth and proliferation …
binds to and stimulates PI3Kα/Akt signaling, promoting cell growth and proliferation …