Solid-state NMR: Methods for biological solids
S Ahlawat, KR Mote, NA Lakomek… - Chemical Reviews, 2022 - ACS Publications
In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …
transformed from a spectroscopic technique investigating small molecules and industrial …
Docking techniques in pharmacology: How much promising?
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[HTML][HTML] Lactate regulates cell cycle by remodelling the anaphase promoting complex
Lactate is abundant in rapidly dividing cells owing to the requirement for elevated glucose
catabolism to support proliferation,,,,–. However, it is not known whether accumulated lactate …
catabolism to support proliferation,,,,–. However, it is not known whether accumulated lactate …
Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
C Gelot, MT Kovacs, S Miron, E Mylne, A Haan… - Nature, 2023 - nature.com
DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity.
To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries …
To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries …
[HTML][HTML] The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
[HTML][HTML] Extreme disorder in an ultrahigh-affinity protein complex
Molecular communication in biology is mediated by protein interactions. According to the
current paradigm, the specificity and affinity required for these interactions are encoded in …
current paradigm, the specificity and affinity required for these interactions are encoded in …
[HTML][HTML] HSP40 proteins use class-specific regulation to drive HSP70 functional diversity
O Faust, M Abayev-Avraham, AS Wentink, M Maurer… - Nature, 2020 - nature.com
The ubiquitous heat shock protein 70 (HSP70) family consists of ATP-dependent molecular
chaperones, which perform numerous cellular functions that affect almost all aspects of the …
chaperones, which perform numerous cellular functions that affect almost all aspects of the …
[HTML][HTML] RNA polymerase II clustering through carboxy-terminal domain phase separation
M Boehning, C Dugast-Darzacq, M Rankovic… - Nature structural & …, 2018 - nature.com
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
Atomic-resolution structure of a disease-relevant Aβ (1–42) amyloid fibril
Amyloid-β (Aβ) is present in humans as a 39-to 42-amino acid residue metabolic product of
the amyloid precursor protein. Although the two predominant forms, Aβ (1–40) and Aβ (1 …
the amyloid precursor protein. Although the two predominant forms, Aβ (1–40) and Aβ (1 …
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …
compartmentalize their function. Cells also concentrate molecules into phase-separated …